5 DOHENY UPDATE  |  Summer 2017  |  Page 3 (continued from page 1) novel investigations of faulty anatomy and function of the eye’s drainage channels. “For number four, I’d have to point to the 2015 U.S. News & World Report naming Doheny Eye Institute as a top ophthalmology program in the nation,” rightfully boasts Dr. Sadda. “Together with our academic, clinical, and research partner UCLA Stein Eye Institute, we stand at a resounding #5 in the U.S. and at #1 on the West Coast.” U.S. News & World Report has ranked Doheny Eye Institute among the top 10 ophthalmology programs for the past 20 years. “For number five, I’d cite the remarkable work by neuro- ophthalmologist Alfredo Sadun, MD, PhD, who came to Doheny Eye Institute from Harvard Medical School in 1984 and commenced to make major discoveries about abnormal mitochondria—the cellular power station—in the optic nerve of patients with Alzheimer’s disease, AIDS, and Leber’s hereditary optic neuropathy (LHON).” Scientists today are looking at faulty mitochondria in another serious eye condition, age-related macular degeneration, which is one of the most common blinding eye disorders in people over 50. “Dr. Sadun is a world expert and leader,” says Dr. Sadda. For that little something extra that defines Doheny Eye Institute, Dr. Sadda adds the Stephen J. Ryan Initiative for Macular Research (RIMR). “Steve believed that curing big medical problems takes teamwork.” So, together with Beckman Foundation founder Arnold Beckman, Dr. Ryan established an annual event where experts in the basic sciences, engineering, physics, mathematics, medical research, artificial intelligence, information technology, and other fields would brainstorm ideas for solving problems of AMD. “Steve rightfully recognized collaboration as the future of science and medicine,” says Dr. Sadda. He is continuing in the same spirit. In truth, the 70-year history of the Doheny Eye Institute contains uncountable examples of expertise and innovation. And the beat goes on—at an even faster pace as Doheny builds its staff of ophthalmologists and researchers, its research collaborations and community-based eyecare centers, and its 100-person strong research enterprise called the Doheny Image Reading Center serving clients worldwide. “We are destined to be the best in the world,” says Dr. Sadda, himself a 21st century leader whose firm hand and focused eye is on the timely challenges and opportunities ahead. n Five Major Events (plus one) in the History of Doheny Eye Institute as told by Doheny president SriniVas Sadda, MD The endowment in 1947 by Estelle Doheny’s that established the Estelle Doheny Eye Foundation The recruitment in 1974 of a youthful Stephen J. Ryan, MD, from The Johns Hopkins School of Medicine The invention in 1992 by George Baerveldt, MD, of the Baerveldt Glaucoma Implant The 2015 U.S. News & World Report naming Doheny and the UCLA Stein Eye Institutes a Top 5 ophthalmology program in the nation The discoveries by neuro-ophthalmologist Alfredo Sadun, MD, PhD, of abnormal mitochondria in several visual disorders PLUS, ONE MORE: Dr. Ryan’s belief that collaboration is the answer to solving big medical problems (For the full story of the illustrious 70-year history of the Doheny Eye Institute, we refer you to the recently published book, A Clear Vision:The History of the Doheny Eye Institute 1947-2017, by Harvard University/UCLA-trained anthropologist and author Laurie Levin. Contact the Development office at (323) 342-7101 to obtain your copy.) 1 2 3 4 5 making discoveries about circadian rhythm-related retinal cells in patients with AD, hoping to explain the sleep disturbances they experience. Fifth, Dr. Sadun points to the steady drumbeat at Doheny Eye Institute that drives research and clinical advances in age-related macular degeneration, the leading cause of vision loss in the U.S. “I know that Steve Ryan would point to Doheny’s early and continued leadership in this field,” says Dr. Sadun, referring to the many initiatives and advances started and nurtured at Doheny Eye Institute. “The heir apparent in this field is our President and Chief Scientific Officer Dr. SriniVas Sadda and the Doheny Image Reading Center he founded, where studying AMD is an imperative.” The beat goes on, louder than ever. n We are destined to be the best in the world